Effects of Acetyl-L-Carnitine on Cardiac Arrhythmias and Infarct Size in Ischemic-Reperfused Isolated Rat Heart

Authors

  • Elnaz Shaseb Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Moslem Najafi Department of Pharmacology, School of Pharmacy, Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
  • Saba Ghaffary Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:

Objective(s) This study aimed to examine whether acetyl-L-carnitine (ALC) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched Krebs solution with 0.375, 0.75, 1.5 and 3 mM of ALC (treatment groups). The ECGs were recorded and analyzed to determine cardiac arrhythmias. The infarct size was determined by using a computerized planimetry package. Results During ischemia, all used concentrations of ALC decreased number and duration of ventricular tachycardia (VT), total number of ventricular ectopic beats (VEBs) (P

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Journal title

volume 13  issue 1

pages  216- 222

publication date 2010-01-01

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